Note: Scoring of VCF files with CADD v1.7 is rather slow if many new variants need to be calculated from scratch, i.e. if thousands of insertion/deletion or multinucleotide subsitutions are included in one scoring request. If you need to calculate scores from scratch for thousands of variants, please consider using the offline scoring scripts from CADD and setting up an internal scoring for your site/institution.
Some users have reported truncated downloads from the US site. We do not see these truncations from the German server. We find that files are being truncated while downloading in Chrome and Edge (to exactly 64 KB on disk, or 63.7KB byte size), but are complete when downloading with Firefox or wget. If you encounter this issue, please use an alternative way of downloading your result files. Very sorry for the inconvenience. We currently do not know how to fix the issue on our side.
Single nucleotide variant (SNV) lookup
This form allows you to quickly access the score (and annotation) of a single nucleotide variant (SNV) or all scores at a specific genomic position. If you are investigating multiple or even ranges of CADD SNV scores, please have a look at our Multi-SNV scoring form. Please note that copying and downloading of the annotation tables is not working in Internet Explorer.
CADD scores are freely available for all non-commercial applications. If you are planning on using them in a commercial application, please contact us.