Note: Scoring of VCF files with CADD v1.7 is rather slow if many new variants need to be calculated from scratch, i.e. if thousands of insertion/deletion or multinucleotide subsitutions are included in one scoring request. If you need to calculate scores from scratch for thousands of variants, please consider using the offline scoring scripts from CADD and setting up an internal scoring for your site/institution.
Some users have reported truncated downloads from the US site. We do not see these truncations from the German server. We find that files are being truncated while downloading in Chrome and Edge (to exactly 64 KB on disk, or 63.7KB byte size), but are complete when downloading with Firefox or wget. If you encounter this issue, please use an alternative way of downloading your result files. Very sorry for the inconvenience. We currently do not know how to fix the issue on our side.
CADD scores are freely available for all non-commercial applications. If you are
planning on using them in a commercial application, please obtain a license. If you have questions, please contact us.
Due to the large file sizes, we highly recommend a download manager or another tool that allows you to continue
interrupted downloads (e.g. wget -c).
Note that the latest versions also have a separate download option via the install script.
Offline scoring scripts for v1.7
Genome build GRCh38 / hg38
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh38/hg38 |
US
| DE (81G)
|
US
| DE
(2.6M) |
| All possible SNVs of GRCh38/hg38 incl. all annotations |
US
| DE
(625G) |
US
| DE
(2.7M) |
| All gnomAD release 4.0 InDels (from genomes only) to initiate a local setup |
US
| DE
(1.2G) |
US
| DE
(1.8M) |
| All gnomAD release 4.0 InDels (from genomes only) incl. all annotations to initiate a local setup |
US
| DE
(11G) |
US
| DE
(2.6M) |
| MD5Sums |
US
| DE |
|
| All GRCh38 annotations required for offline installation |
US
| DE
(336G) |
|
Genome build GRCh37 / hg19
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (79G)
|
US
| DE
(2.6M) |
| All possible SNVs of GRCh37/hg19 incl. all annotations |
US
| DE
(562G) |
US
| DE
(2.7M) |
| Liftover gnomAD v4 InDels (from genomes and exomes) to initiate a local setup |
US
| DE (1.4G) |
US
| DE (1.9M) |
| Liftover gnomAD v4 InDels (from genomes and exomes) incl. all annotations to initiate a local setup |
US
| DE (10G)
|
US
| DE
(2.5M) |
| MD5Sums |
US
| DE |
|
| All GRCh37 annotations required for offline installation |
US
| DE
(261G) |
|
Offline scoring scripts for v1.6
Genome build GRCh38 / hg38
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh38/hg38 |
US
| DE (81G) |
US
| DE (2.6M)
|
| All possible SNVs of GRCh38/hg38 incl. all annotations |
US
| DE
(313G) |
US
| DE
(2.7M) |
| All gnomad release 3.0 InDels to initiate a local setup |
US
| DE
(1.1G) |
US
| DE
(1.8M) |
| All gnomad release 3.0 InDels incl. all annotations to initiate a local setup |
US
| DE
(7.2G) |
US
| DE
(2.5M) |
| All gnomad release 3.0 SNVs |
US
| DE (5.9G)
|
US
| DE
(2.4M) |
| MD5Sums |
US
| DE |
|
| All GRCh38 annotations required for offline installation |
US
| DE (206G)
|
|
Genome build GRCh37 / hg19
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (78G) |
US
| DE (2.6M)
|
| All possible SNVs of GRCh37/hg19 incl. all annotations |
US
| DE
(248G) |
US
| DE
(2.6M) |
| 48M InDels to initiate a local setup |
US
| DE (591M) |
US
| DE (1.7M) |
| 48M InDels incl. all annotations to initiate a local setup |
US
| DE (3.5G) |
US
| DE (2.4M)
|
| All gnomAD SNVs (release 2.1.1) |
US
| DE
(2.3G) |
US
| DE
(2.0M) |
| All gnomAD InDels (release 2.1.1) |
US
| DE
(387M) |
US
| DE
(1.6M) |
| MD5Sums |
US
| DE |
|
| All GRCh37 annotations required for offline installation |
US
| DE (129G)
|
|
Offline scoring scripts for v1.4 and v1.5
Genome build GRCh38 / hg38
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh38/hg38 |
US
| DE (80G) |
US
| DE (2.7M)
|
| All possible SNVs of GRCh38/hg38 incl. all annotations |
US
| DE
(292G) |
US
| DE
(2.7M) |
| 80M InDels to initiate a local setup |
US
| DE (948M) |
US
| DE (1.8M) |
| 80M InDels incl. all annotations to initiate a local setup |
US
| DE (6.8G) |
US
| DE (2.4M)
|
| All BRAVO/TOPMed variants (freeze 5) |
US
| DE
(5.5G) |
US
| DE
(2.4M) |
| MD5Sums |
US
| DE |
|
| All annotations required for offline installation |
US
| DE (168G) |
|
Genome build GRCh37 / hg19
No new model was generated, please use CADD v1.4 for GRCh37.
Genome build GRCh38 / hg38
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh38/hg38 |
US
| DE (79G) |
US
| DE (2.7M)
|
| All possible SNVs of GRCh38/hg38 incl. all annotations |
US
| DE
(323G) |
US
| DE
(2.7M) |
| 80M InDels to initiate a local setup |
US
| DE (948M) |
US
| DE (1.8M) |
| 80M InDels incl. all annotations to initiate a local setup |
US
| DE (8.8G) |
US
| DE (2.5M)
|
| All BRAVO/TOPMed variants (freeze 5) |
US
| DE
(5.5G) |
US
| DE
(2.4M) |
| MD5Sums |
US
| DE |
|
| All GRCh38 annotations required for offline installation |
US
| DE (194G) |
|
Genome build GRCh37 / hg19
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (78G) |
US
| DE (2.6M)
|
| All possible SNVs of GRCh37/hg19 incl. all annotations |
US
| DE
(231G) |
US
| DE
(2.6M) |
| 48M InDels to initiate a local setup |
US
| DE (588M) |
US
| DE (1.6M) |
| 48M InDels incl. all annotations to initiate a local setup |
US
| DE (3.3G) |
US
| DE (2.2M)
|
| All gnomAD variants (release 2.0.1) |
US
| DE
(2.7G) |
US
| DE
(2.1M) |
| MD5Sums |
US
| DE |
|
| All GRCh37 annotations required for offline installation |
US
| DE (98G) |
|
| Description |
Link (Size) |
Tabix Index (Size) |
| 1000 phase 3 Genome variants (SNVs and InDels) |
US
| DE (885M) |
US
| DE (1.8M) |
| 1000 phase 3 Genome variants (SNVs and InDels) incl. all annotations |
US
| DE (6.1G) |
US
| DE (2.5M) |
| 1000 Genome variants (SNVs and InDels) |
US
| DE (450M) |
US
| DE (1.6M) |
| 1000 Genome variants (SNVs and InDels) incl. all annotations |
US
| DE (3.3G) |
US
| DE (2.4M) |
| ESP6500 variants (SNVs and InDels) |
US
| DE (22M) |
US
| DE (524K) |
| ESP6500 variants (SNVs and InDels) incl. all annotations |
US
| DE (224M) |
US
| DE (632K) |
| Exome Aggregation Consortium variants (r0.3) |
US
| DE (108M) |
US
| DE (592K) |
| Exome Aggregation Consortium variants (r0.3) incl. annotation |
US
| DE (954M) |
US
| DE (811K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE (2.6M) |
US
| DE (408K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE (33M)
|
US
| DE
(476K) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (80G) |
US
| DE (2.7M) |
| All possible SNVs of GRCh37/hg19 incl. all annotations |
US
| DE (344G)
|
US
| DE (2.7M)
|
| 20M InDels to initiate a local setup |
US
| DE (268M) |
US
| DE (1.6M) |
| 20M InDels incl. all annotations to initiate a local setup |
US
| DE (1.6G) |
US
| DE (2.3M) |
| All annotation tracks required for offline installation of v1.3 |
US
| DE (206G) |
| Update of the primate WGA data required for offline installation of v1.3 |
US
| DE (3.1G) |
| Scripts and README for offline installation |
US
| DE (132K) |
| MD5Sums |
US
| DE |
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (79G) |
US
| DE (2.7M) |
| All possible SNVs of GRCh37/hg19 incl. all annotations |
US
| DE (342G)
|
US
| DE (2.7M)
|
| 1000 Genome variants (SNVs and InDels) |
US
| DE (449M) |
US
| DE (1.7M) |
| 1000 Genome variants (SNVs and InDels) incl. all annotations |
US
| DE (3.3G) |
US
| DE (2.4M) |
| ESP6500 variants (SNVs and InDels) |
US
| DE (22M) |
US
| DE (532K) |
| ESP6500 variants (SNVs and InDels) incl. all annotations |
US
| DE (224M) |
US
| DE (650K) |
| Exome Aggregation Consortium variants (r0.2) |
US
| DE (108M) |
US
| DE (609K) |
| Exome Aggregation Consortium variants (r0.2) incl. annotation |
US
| DE (954M) |
US
| DE (811K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE (2.6M) |
US
| DE (418K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE (33M)
|
US
| DE
(493K) |
| 20M InDels to initiate a local setup |
US
| DE (267M) |
US
| DE (1.6M) |
| 20M InDels incl. all annotations to initiate a local setup |
US
| DE (1.6G) |
US
| DE (2.3M) |
| All annotation tracks required for offline installation |
US
| DE (206G) |
| Scripts and README for offline installation |
US
| DE (132K) |
| MD5Sums |
US
| DE |
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (80G) |
US
| DE (2.7M) |
| All possible SNVs of GRCh37/hg19 incl. all annotations |
US
| DE (279G)
|
US
| DE (2.7M)
|
| 1000 Genome variants (SNVs and InDels) |
US
| DE (449M) |
US
| DE (1.6M) |
| 1000 Genome variants (SNVs and InDels) incl. all annotations |
US
| DE (3.3G) |
US
| DE (2.4M) |
| ESP6500 variants (SNVs and InDels) |
US
| DE (22M) |
US
| DE (524K) |
| ESP6500 variants (SNVs and InDels) incl. all annotations |
US
| DE (224M) |
US
| DE (628K) |
| Exome Aggregation Consortium variants (r0.1) |
US
| DE (111M) |
US
| DE (592K) |
| Exome Aggregation Consortium variants (r0.1) incl. annotation |
US
| DE (955M) |
US
| DE (800K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE (2.6M) |
US
| DE (408K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE (33M)
|
US
| DE
(476K) |
| 14M InDels to initiate a local setup |
US
| DE (194M) |
US
| DE (1.6M) |
| 14M InDels incl. all annotations to initiate a local setup |
US
| DE (1.1G) |
US
| DE (2.1M) |
| All annotation tracks required for offline installation |
US
| DE (206G) |
| Scripts and README for offline installation |
US
| DE (132K) |
| MD5Sums |
US
| DE |
Published version: v1.0
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (79G) |
US
| DE (2.7M) |
| All possible SNVs of GRCh37/hg19 incl. all annotations |
US
| DE (218G)
|
US
| DE (2.7M)
|
| 1000 Genome variants (SNVs and InDels) |
US
| DE (445M) |
US
| DE (1.7M) |
| ESP6500 variants (SNVs and InDels) |
US
| DE (22M) |
US
| DE (643K) |
| Exome Aggregation Consortium variants (r0.1) |
US
| DE (113M) |
US
| DE (609K) |
| Exome Aggregation Consortium variants (r0.1) incl. annotation |
US
| DE (656M) |
US
| DE (778K) |
| Exome Aggregation Consortium variants (r0.3) |
US
| DE (105M) |
US
| DE (609K) |
| Exome Aggregation Consortium variants (r0.3) incl. annotation |
US
| DE (643M) |
US
| DE (778K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE
(2.7M) |
US
| DE
(404K) |
| 12.3M InDels to initiate a local setup |
US
| DE (162M) |
US
| DE (1.7M) |
| 12.3M InDels incl. all annotations to initiate a local setup |
US
| DE (648M) |
US
| DE (2.1M) |
| MD5Sums |
US
| DE |
Earlier developmental release version: v0.5
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (77G) |
US
| DE (2.7M) |
| 1000 Genome variants (SNVs and InDels) |
US
| DE (448M) |
US
| DE (1.7M) |
| ESP6500 variants (SNVs and InDels) |
US
| DE (21M) |
US
| DE (643K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE
(2.5M) |
US
| DE
(400K) |
| MD5Sums |
US
| DE |