Track-Hub of CADD scores for UCSC Genome Browser
This is information regarding the UCSC genome browser track hub for CADD versions v1.3 to v1.6 on hg19 and hg38. There is also limited support for NCBI genome data viewer and Ensembl genome browser. The track displayes the highest CADD score of any 3 possible SNVs for a genomic position. It is available for every determined (i.e. non-N) position on the major chromosomes of the reference genome.
Our latest manuscript describes the updates since the initial publication of CADD including these UCSC Genome Browser tracks. It was published by Nucleic Acids Research in 2018:
Rentzsch P, Witten D, Cooper GM, Shendure J, Kircher M.The original manuscript describing the CADD method was published by Nature Genetics in 2014:
CADD: predicting the deleteriousness of variants throughout the human genome.
Nucleic Acids Res. 2018 Oct 29. doi: 10.1093/nar/gky1016.
PubMed PMID: 30371827.
Kircher M, Witten DM, Jain P, O'Roak BJ, Cooper GM, Shendure J.
A general framework for estimating the relative pathogenicity of human genetic variants.
Nat Genet. 2014 Feb 2. doi: 10.1038/ng.2892.
PubMed PMID: 24487276.
If you have technical problems using the CADD track-hub, please check the information provided in the readme. If this does not resolve your issues, please contact us at cadd-support [at] uw.edu.