Note: Scoring of VCF files with CADD v1.7 is rather slow if many new variants need to be calculated from scratch, i.e. if thousands of insertion/deletion or multinucleotide subsitutions are included in one scoring request. If you need to calculate scores from scratch for thousands of variants, please consider using the offline scoring scripts from CADD and setting up an internal scoring for your site/institution.

Some users have reported truncated downloads from the US site. We do not see these truncations from the German server. We find that files are being truncated while downloading in Chrome and Edge (to exactly 64 KB on disk, or 63.7KB byte size), but are complete when downloading with Firefox or wget. If you encounter this issue, please use an alternative way of downloading your result files. Very sorry for the inconvenience. We currently do not know how to fix the issue on our side.

How to contact us?

If you have technical problems using CADD, please check the information provided here. If this does not resolve your issues, please contact us at cadd-support [at] uw.edu.

CADD is currently developed by Martin Kircher, Max Schubach, Thorben Maaß, and Lusine Nazaretyan.

Former developers are Philipp Rentzsch, Sebastian Röner, Daniela M. Witten, Gregory M. Cooper, and Jay Shendure.

If you are planning on using CADD in a commercial application, you can obtain a license through the UW CoMotion Express Licensing System. If in doubt about whether you need a license for your application, please contact Jay Shendure and Gregory M. Cooper.