Combined Annotation Dependent Depletion (CADD)

CADD scores are freely available for all non-commercial applications. If you are planning on using them in a commercial application, please contact us.

Due to the large file sizes, we highly recommend a download manager or another tool that allows you to continue interrupted downloads (e.g. wget -c).

Current version/developmental release: v1.3 [release notes]

1000 phase 3 Genome variants (SNVs and InDels)   [ file (885M) | tabix index (1.8M) ]

1000 phase 3 Genome variants (SNVs and InDels) incl. all annotations   [ file (6.1G) | tabix index (2.5M) ]

1000 Genome variants (SNVs and InDels)   [ file (450M) | tabix index (1.6M) ]

1000 Genome variants (SNVs and InDels) incl. all annotations   [ file (3.3G) | tabix index (2.4M) ]

ESP6500 variants (SNVs and InDels)   [ file (22M) | tabix index (524K) ]

ESP6500 variants (SNVs and InDels) incl. all annotations   [ file (224M) | tabix index (632K) ]

Exome Aggregation Consortium variants (r0.3)   [ file (108M) | tabix index (592K) ]

Exome Aggregation Consortium variants (r0.3) incl. annotation   [ file (954M) | tabix index (811K) ]

SNV variants on Illumina Exome BeadChip   [ file (2.6M) | tabix index (408K) ]

SNV variants on Illumina Exome BeadChip   [ file (33M) | tabix index (476K) ]

All possible SNVs of GRCh37/hg19   [ file (80G) | tabix index (2.7M) ]

All possible SNVs of GRCh37/hg19 incl. all annotations   [ file (344G) | tabix index (2.7M) ]

20M InDels to initiate a local setup   [ file (268M) | tabix index (1.6M) ]

20M InDels incl. all annotations to initiate a local setup   [ file (1.6G) | tabix index (2.3M) ]

All annotation tracks required for offline installation of v1.2   [ file (206G) ]

Update of the primate WGA data required for offline installation of v1.3   [ file (3.1G) ]

Scripts and README for offline installation   [ file (132K) ]

MD5 checksums

272ad1f3ec1353d450ecdc23ef489951 1000G_phase3_inclAnno.tsv.gz
caa51bc6c7639b4ffc10d9e9622c4216 1000G_phase3_inclAnno.tsv.gz.tbi
790a59f60f4475763d94126d95291b19 1000G_phase3.tsv.gz
63e683b03468bf0d56efe3a699a7e501 1000G_phase3.tsv.gz.tbi
6e19b8a4aa9cf472e1b9588bfa6dab86 1000G_inclAnno.tsv.gz
7c17efd398050e8cb506adccbe98d348 1000G_inclAnno.tsv.gz.tbi
905996fef31b8da11d4ebfb326e32976 1000G.tsv.gz
fbfc4c38d148a4964c91e47dc4618275 1000G.tsv.gz.tbi
7967c063a678cbfece90a2892f4a8777 ESP6500SI_inclAnno.tsv.gz
4deb56ead889fb012970d1dde4cad731 ESP6500SI_inclAnno.tsv.gz.tbi
4c0eab5e64ef7a73541578115dcf4cbf ESP6500SI.tsv.gz
58b75c16424623ab53e93545c87e14f2 ESP6500SI.tsv.gz.tbi
04743c7bfefd9e274a654dc153e91a21 ExAC_r0.3_inclAnno.tsv.gz
30e8e708a48b863af705161e42d3c369 ExAC_r0.3_inclAnno.tsv.gz.tbi
d4851dd0a9e48ba24293ab5457baccbb ExAC_r0.3.tsv.gz
63991359c6692a8fdb27aa868cc4d353 ExAC_r0.3.tsv.gz.tbi
30053f9d08d1649044b98890a92ac326 HumanExome-12v1-1_A_inclAnno.tsv.gz
73ffa63eccecbfd06151fc403094aa5f HumanExome-12v1-1_A_inclAnno.tsv.gz.tbi
113c42fadb7600b9a021c4ac9b55b6bc HumanExome-12v1-1_A.tsv.gz
68cc400861a477bf013f0ce0999999b1 HumanExome-12v1-1_A.tsv.gz.tbi
aca5795946b37c13a5170bd8554f5833 whole_genome_SNVs.tsv.gz
8b2284bb66e327651bd64850a3f0a910 whole_geno me_SNVs.tsv.gz.tbi
4db20ee3ac9787e78c5b2ac819c2aca8 whole_genome_SNVs_inclAnno.tsv.gz
56622ba80f255d356e9356e911f7c7fd whole_genome_SNVs_inclAnno.tsv.gz.tbi
dda1fb1f301f9a18722da655cd18e720 InDels_inclAnno.tsv.gz
c08bfeeb9a081874e9ab2af3e6c2b710 InDels_inclAnno.tsv.gz.tbi
add232ba847cb2bb862983f445a9482d InDels.tsv.gz
37d98e4da9f6a61aab9f3db179f9f69f InDels.tsv.gz.tbi
dc43f2a3b4e07150639fce6fefac006b annotations.tgz
a2a667958fbe2650d3dfd3f1513e1f17 primateWGA_annoUpdate.tgz
ae55f90dd1041650009965532d09933d cadd_v1.3_scripts.tgz

Current version/developmental release: v1.2 [release notes]

All possible SNVs of GRCh37/hg19   [ file (79G) | tabix index (2.7M) ]

All possible SNVs of GRCh37/hg19 incl. all annotations   [ file (342G) | tabix index (2.7M) ]

1000 Genome variants (SNVs and InDels)   [ file (449M) | tabix index (1.7M) ]

1000 Genome variants (SNVs and InDels) incl. all annotations   [ file (3.3G) | tabix index (2.4M) ]

ESP6500 variants (SNVs and InDels)   [ file (22M) | tabix index (532K) ]

ESP6500 variants (SNVs and InDels) incl. all annotations   [ file (224M) | tabix index (650K) ]

Exome Aggregation Consortium variants (r0.2)   [ file (108M) | tabix index (609K) ]

Exome Aggregation Consortium variants (r0.2) incl. annotation   [ file (954M) | tabix index (811K) ]

SNV variants on Illumina Exome BeadChip   [ file (2.6M) | tabix index (418K) ]

SNV variants on Illumina Exome BeadChip   [ file (33M) | tabix index (493K) ]

20M InDels to initiate a local setup   [ file (267M) | tabix index (1.6M) ]

20M InDels incl. all annotations to initiate a local setup   [ file (1.6G) | tabix index (2.3M) ]

All annotation tracks required for offline installation  [ file (206G) ]

Scripts and README for offline installation   [ file (132K) ]

MD5 checksums

65e1ea7e9e42a8d19545b49a2970a1e4 1000G_inclAnno.tsv.gz
9f5341364865de616ed49501c2f90b05 1000G_inclAnno.tsv.gz.tbi
d639bf8a8841812c291b25326ded5715 1000G.tsv.gz
741289457ef96a16957fc79490e8a221 1000G.tsv.gz.tbi
59c0fd8b9ad59e1bd423f2355e1e003f ESP6500SI_inclAnno.tsv.gz
ebef795d67ede32e4f6d138b6e15eeda ESP6500SI_inclAnno.tsv.gz.tbi
3df3996689088107b23a68fe9963ef06 ESP6500SI.tsv.gz
0a7f29a7b2c5320c96fbdc4708c0f700 ESP6500SI.tsv.gz.tbi
a33db8c53c0f1358c6e86d41a615e1af ExAC.r0.2_inclAnno.tsv.gz
471076f0d221048a9ea6f01e2009e3c2 ExAC.r0.2_inclAnno.tsv.gz.tbi
d4a8262e01c16f3a06e65b507650f9b5 ExAC.r0.2.tsv.gz
b81c992e3e1ccf4e511bfd44f560c556 ExAC.r0.2.tsv.gz.tbi
de828ea4a9296a8dd82cb30871f132bb HumanExome-12v1-1_A_inclAnno.tsv.gz
dacd611172bc0a18f0a673a99be0f5db HumanExome-12v1-1_A_inclAnno.tsv.gz.tbi
d8c21e45f8f31945802f525310344462 HumanExome-12v1-1_A.tsv.gz
d310c06049b01f4360cff747d9e48250 HumanExome-12v1-1_A.tsv.gz.tbi
ff108bba0b433a8bccca4f4dd136637a InDels_inclAnno.tsv.gz
2c0960e1d697564dd852463895b3e4d7 InDels_inclAnno.tsv.gz.tbi
189ae9bf1d21468f42b358d42422d1af InDels.tsv.gz
1b4201117785a0f21334a1885d207cae InDels.tsv.gz.tbi
b3bf45f09f81f4523c6d2074158148da whole_genome_SNVs_inclAnno.tsv.gz
a6b33ecc20cab4a31e7131578fbbbb1f whole_genome_SNVs_inclAnno.tsv.gz.tbi
1938a67d9c00ac5ac5a2dc2b9246ad27 whole_genome_SNVs.tsv.gz
17810876ee835194ae3cb8fbd91700e4 whole_geno me_SNVs.tsv.gz.tbi
dc43f2a3b4e07150639fce6fefac006b annotations.tgz
667cfd1538b1eda5ce2d0496085f18ca cadd_v1.2_scripts.tgz

Developmental release: v1.1 [release notes]

All possible SNVs of GRCh37/hg19   [ file (80G) | tabix index (2.7M) ]

All possible SNVs of GRCh37/hg19 incl. all annotations   [ file (279G) | tabix index (2.7M) ]

1000 Genome variants (SNVs and InDels)   [ file (449M) | tabix index (1.6M) ]

1000 Genome variants (SNVs and InDels) incl. all annotations   [ file (3.3G) | tabix index (2.4M) ]

ESP6500 variants (SNVs and InDels)   [ file (22M) | tabix index (524K) ]

ESP6500 variants (SNVs and InDels) incl. all annotations   [ file (224M) | tabix index (628K) ]

Exome Aggregation Consortium variants (r0.1)   [ file (111M) | tabix index (592K) ]

Exome Aggregation Consortium variants (r0.1) incl. annotation   [ file (955M) | tabix index (800K) ]

SNV variants on Illumina Exome BeadChip   [ file (2.6M) | tabix index (408K) ]

SNV variants on Illumina Exome BeadChip   [ file (33M) | tabix index (476K) ]

14M InDels to initiate a local setup   [ file (194M) | tabix index (1.6M) ]

14M InDels incl. all annotations to initiate a local setup   [ file (1.1G) | tabix index (2.1M) ]

All annotation tracks required for offline installation  [ file (206G) ]

Scripts and README for offline installation   [ file (132K) ]

MD5 checksums

7d3ace746f79857c5dcc7faf9938444f 1000G_inclAnno.tsv.gz
316e8d4b683a24a425cff7651553532a 1000G_inclAnno.tsv.gz.tbi
e084dbef6688ce00718eeefefd50488f 1000G.tsv.gz
38e1828974c11c8ab8a808f38dfb19b9 1000G.tsv.gz.tbi
02d150f3f329a73b168e0a8a36d1fa7c ESP6500SI_inclAnno.tsv.gz
1209c27bf0b6a351a365d5f7fbe16314 ESP6500SI_inclAnno.tsv.gz.tbi
e79d177eecd6ccbb0aa3ffe0eb85b004 ESP6500SI.tsv.gz
e2b8aa662a95bbf6439fdecb43ef7629 ESP6500SI.tsv.gz.tbi
0a2b743ce8714214520fd156b2b4b667 ExAC.r0.1_inclAnno.tsv.gz
890a16a169b6b9804be071ce3bca4999 ExAC.r0.1_inclAnno.tsv.gz.tbi
bf9826b2e4a5018b55a6fd8a5f9a949e ExAC.r0.1.tsv.gz
f66e256bd45e742b06357fae258c1a4d ExAC.r0.1.tsv.gz.tbi
9de0bd85470278d04a086b79ea95b267 HumanExome-12v1-1_A_inclAnno.tsv.gz
b1ff89799024f2816e8b874fc5c8f76e HumanExome-12v1-1_A_inclAnno.tsv.gz.tbi
3e3d2f3ceb00312a57752be431e58fd4 HumanExome-12v1-1_A.tsv.gz
dc3a7914a1c3faed34f09e63a1a983b4 HumanExome-12v1-1_A.tsv.gz.tbi
2e5d63b1b8804a3ef97f8b067e5e408c InDels_inclAnno.tsv.gz
658fee68499393d67046eaf50b180786 InDels_inclAnno.tsv.gz.tbi
4796164953fcc98568b48285a6c9db2e InDels.tsv.gz
e215734655defe47f7f2d4cebea78aec InDels.tsv.gz.tbi
602d4363704ed2858f93403f6c6c985c whole_genome_SNVs_inclAnno.tsv.gz
3b707504c56e3ecd92502fba26a2268c whole_genome_SNVs_inclAnno.tsv.gz.tbi
b4af387174d80f56a7ee4f1c7cf6d725 whole_genome_SNVs.tsv.gz
e07e8547592a67e939c041f30ed4c985 whole_genome_SNVs.tsv.gz.tbi
dc43f2a3b4e07150639fce6fefac006b annotations.tgz
546d7ce9039bb2c38dba890f146fe9ef cadd_v1.1_scripts.tgz

Published version: v1.0

All possible SNVs of GRCh37/hg19   [ file (79G) | tabix index (2.7M) ]

All possible SNVs of GRCh37/hg19 incl. all annotations   [ file (218G) | tabix index (2.7M) ]

1000 Genome variants (SNVs and InDels)   [ file (445M) | tabix index (1.7M) ]

ESP6500 variants (SNVs and InDels)   [ file (22M) | tabix index (643K) ]

Exome Aggregation Consortium variants (r0.1)   [ file (113M) | tabix index (609K) ]

Exome Aggregation Consortium variants (r0.1) incl. annotation   [ file (656M) | tabix index (778K) ]

Exome Aggregation Consortium variants (r0.3)   [ file (105M) | tabix index (609K) ]

Exome Aggregation Consortium variants (r0.3) incl. annotation   [ file (643M) | tabix index (778K) ]

SNV variants on Illumina Exome BeadChip   [ file (2.7M) | tabix index (404K) ]

12.3M InDels to initiate a local setup   [ file (162M) | tabix index (1.7M) ]

12.3M InDels incl. all annotations to initiate a local setup   [ file (648M) | tabix index (2.1M) ]

MD5 checksums

bec611d96ac2c12bf0f8ead1f2afc935 1000G.tsv.gz
03fe04988f5c7c6d5806ffd0588ddae4 1000G.tsv.gz.tbi
dc7982bb2aa969ae31e0c874912b668f ESP6500SI.tsv.gz
826756369bc6d5cf14a2128da91a520c ESP6500SI.tsv.gz.tbi
f9631aa9d3e3422601fcec539cadc8d9 ExAC.r0.1.inclAnno.tsv.gz
2b67375537d21290cd971edbfbfae268 ExAC.r0.1.inclAnno.tsv.gz.tbi
155cdd391e156c2dc7ee5486720abfed ExAC.r0.1.tsv.gz
c2d9f850e8b107b7b870004b7461e075 ExAC.r0.1.tsv.gz.tbi
8d6d8f0ced749c05ded1e25c109b1f01 ExAC.r0.3.inclAnno.tsv.gz
c958f572911d594b4cfb84517ae747b1 ExAC.r0.3.inclAnno.tsv.gz.tbi
7dd91e51a996aeba281a60f9d2e547db ExAC.r0.3.tsv.gz
3d607ef0c63c5a7920b99a8077ee4e82 ExAC.r0.3.tsv.gz.tbi
b0614da7b1d5ad9a1f3b1d6a97e8448d HumanExome-12v1-1_A.SNVs.pscored.tsv.gz
31611ab943fcc1ff8f928fc697877d2d HumanExome-12v1-1_A.SNVs.pscored.tsv.gz.tbi
624d8d16710309d5ac2822948acbf57c InDels_inclAnno.tsv.gz
ace37c6a821ebae5dd1518306b09fff9 InDels_inclAnno.tsv.gz.tbi
1811bb189cf7adedd78d3f31c656fcfe InDels.tsv.gz
08b33830f134822810971ee30c0de0dc InDels.tsv.gz.tbi
796ca07464fac065ec26cf8f79c1f0d6 whole_genome_SNVs_inclAnno.tsv.gz
46fd0d0b589fd4e24bd5ee455142ae8d whole_genome_SNVs_inclAnno.tsv.gz.tbi
93634f45987dc39b12ab9ccf45d61b7a whole_genome_SNVs.tsv.gz
8e9a187ea3d06461f76b8145f7b3a24e whole_genome_SNVs.tsv.gz.tbi

Earlier developmental release version: v0.5

All possible SNVs of GRCh37/hg19   [ file (77G) | tabix index (2.7M) ]

1000 Genome variants (SNVs and InDels)   [ file (448M) | tabix index (1.7M) ]

ESP6500 variants (SNVs and InDels)   [ file (21M) | tabix index (643K) ]

SNV variants on Illumina Exome BeadChip   [ file (2.5M) | tabix index (400K) ]

MD5 checksums

e6fdb5e064ffe41f8b8e39b868f8377c 1000G.tsv.gz
9351afc06237388b12cf8b103e6451da 1000G.tsv.gz.tbi
ec4deedb7d98f85d7ce179041525a53d ESP6500SI.tsv.gz
eab6e45456d1616e2c38ec9cf761b57c ESP6500SI.tsv.gz.tbi
8484f4f64fe5eaaae8c03bfc3479569c HumanExome-12v1-1_A.SNVs.pscored.tsv.gz
b7e4ffcc1f62a466cdf8daa83f9c1103 HumanExome-12v1-1_A.SNVs.pscored.tsv.gz.tbi
f8d2d6531439cd5d4b54ab6532692ae2 whole_genome_SNVs.tsv.gz
990e40f759a0c947649d95e655324f2a whole_genome_SNVs.tsv.gz.tbi

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