Combined Annotation Dependent Depletion (CADD)

CADD scores are freely available for all non-commercial applications. If you are planning on using them in a commercial application, please contact us.

Due to the large file sizes, we highly recommend a download manager or another tool that allows you to continue interrupted downloads (e.g. wget -c).

Current developmental release: v1.4 [release notes]

Genome build GRCh38 / hg38

Description Link (Size) Tabix Index (Size)
All possible SNVs of GRCh38/hg38 file (79G) tabix index (2.7M)
All possible SNVs of GRCh38/hg38 incl. all annotations file (323G) tabix index (2.7M)
80M InDels to initiate a local setup file (948M) tabix index (1.8M)
80M InDels incl. all annotations to initiate a local setup file (8.8G) tabix index (2.5M)
All BRAVO/TOPMed variants (freeze 5) file (2.7G) tabix index (2.1M)
MD5Sums file

Genome build GRCh37 / hg19

Description Link (Size) Tabix Index (Size)
All possible SNVs of GRCh37/hg19 file (78G) tabix index (2.6M)
All possible SNVs of GRCh37/hg19 incl. all annotations file (231G) tabix index (2.6M)
48M InDels to initiate a local setup file (588M) tabix index (1.6M)
48M InDels incl. all annotations to initiate a local setup file (3.3G) tabix index (2.2M)
All gnomAD variants (release 2.0.1) file (2.7G) tabix index (2.1M)
MD5Sums file

Offline scripts and required annotations

Scripts and README for offline installation file (360K)
All GRCh38 annotation tracks required for offline installation file (194G)
All GRCh37 annotation tracks required for offline installation file (98G)

Developmental release: v1.3 [release notes]

Description Link (Size) Tabix Index (Size)
1000 phase 3 Genome variants (SNVs and InDels) file (885M) tabix index (1.8M)
1000 phase 3 Genome variants (SNVs and InDels) incl. all annotations file (6.1G) tabix index (2.5M)
1000 Genome variants (SNVs and InDels) file (450M) tabix index (1.6M)
1000 Genome variants (SNVs and InDels) incl. all annotations file (3.3G) tabix index (2.4M)
ESP6500 variants (SNVs and InDels) file (22M) tabix index (524K)
ESP6500 variants (SNVs and InDels) incl. all annotations file (224M) tabix index (632K)
Exome Aggregation Consortium variants (r0.3) file (108M) tabix index (592K)
Exome Aggregation Consortium variants (r0.3) incl. annotation file (954M) tabix index (811K)
SNV variants on Illumina Exome BeadChip file (2.6M) tabix index (408K)
SNV variants on Illumina Exome BeadChip file (33M) tabix index (476K)
All possible SNVs of GRCh37/hg19 file (80G) tabix index (2.7M)
All possible SNVs of GRCh37/hg19 incl. all annotations file (344G) tabix index (2.7M)
20M InDels to initiate a local setup file (268M) tabix index (1.6M)
20M InDels incl. all annotations to initiate a local setup file (1.6G) tabix index (2.3M)
All annotation tracks required for offline installation of v1.3 file (206G)
Update of the primate WGA data required for offline installation of v1.3 file (3.1G)
Scripts and README for offline installation file (132K)
MD5Sums file

Developmental release: v1.2 [release notes]

Description Link (Size) Tabix Index (Size)
All possible SNVs of GRCh37/hg19 file (79G) tabix index (2.7M)
All possible SNVs of GRCh37/hg19 incl. all annotations file (342G) tabix index (2.7M)
1000 Genome variants (SNVs and InDels) file (449M) tabix index (1.7M)
1000 Genome variants (SNVs and InDels) incl. all annotations file (3.3G) tabix index (2.4M)
ESP6500 variants (SNVs and InDels) file (22M) tabix index (532K)
ESP6500 variants (SNVs and InDels) incl. all annotations file (224M) tabix index (650K)
Exome Aggregation Consortium variants (r0.2) file (108M) tabix index (609K)
Exome Aggregation Consortium variants (r0.2) incl. annotation file (954M) tabix index (811K)
SNV variants on Illumina Exome BeadChip file (2.6M) tabix index (418K)
SNV variants on Illumina Exome BeadChip file (33M) tabix index (493K)
20M InDels to initiate a local setup file (267M) tabix index (1.6M)
20M InDels incl. all annotations to initiate a local setup file (1.6G) tabix index (2.3M)
All annotation tracks required for offline installation file (206G)
Scripts and README for offline installation file (132K)
MD5Sums file

Developmental release: v1.1 [release notes]

Description Link (Size) Tabix Index (Size)
All possible SNVs of GRCh37/hg19 file (80G) tabix index (2.7M)
All possible SNVs of GRCh37/hg19 incl. all annotations file (279G) tabix index (2.7M)
1000 Genome variants (SNVs and InDels) file (449M) tabix index (1.6M)
1000 Genome variants (SNVs and InDels) incl. all annotations file (3.3G) tabix index (2.4M)
ESP6500 variants (SNVs and InDels) file (22M) tabix index (524K)
ESP6500 variants (SNVs and InDels) incl. all annotations file (224M) tabix index (628K)
Exome Aggregation Consortium variants (r0.1) file (111M) tabix index (592K)
Exome Aggregation Consortium variants (r0.1) incl. annotation file (955M) tabix index (800K)
SNV variants on Illumina Exome BeadChip file (2.6M) tabix index (408K)
SNV variants on Illumina Exome BeadChip file (33M) tabix index (476K)
14M InDels to initiate a local setup file (194M) tabix index (1.6M)
14M InDels incl. all annotations to initiate a local setup file (1.1G) tabix index (2.1M)
All annotation tracks required for offline installation file (206G)
Scripts and README for offline installation file (132K)
MD5Sums file

Published version: v1.0

Description Link (Size) Tabix Index (Size)
All possible SNVs of GRCh37/hg19 file (79G) tabix index (2.7M)
All possible SNVs of GRCh37/hg19 incl. all annotations file (218G) tabix index (2.7M)
1000 Genome variants (SNVs and InDels) file (445M) tabix index (1.7M)
ESP6500 variants (SNVs and InDels) file (22M) tabix index (643K)
Exome Aggregation Consortium variants (r0.1) file (113M) tabix index (609K)
Exome Aggregation Consortium variants (r0.1) incl. annotation file (656M) tabix index (778K)
Exome Aggregation Consortium variants (r0.3) file (105M) tabix index (609K)
Exome Aggregation Consortium variants (r0.3) incl. annotation file (643M) tabix index (778K)
SNV variants on Illumina Exome BeadChip file (2.7M) tabix index (404K)
12.3M InDels to initiate a local setup file (162M) tabix index (1.7M)
12.3M InDels incl. all annotations to initiate a local setup file (648M) tabix index (2.1M)
MD5Sums file

Earlier developmental release version: v0.5

Description Link (Size) Tabix Index (Size)
All possible SNVs of GRCh37/hg19 file (77G) tabix index (2.7M)
1000 Genome variants (SNVs and InDels) file (448M) tabix index (1.7M)
ESP6500 variants (SNVs and InDels) file (21M) tabix index (643K)
SNV variants on Illumina Exome BeadChip file (2.5M) tabix index (400K)
MD5Sums file

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